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Chemical Structure : Vafidemstat
CAS No.: 1357362-02-7
Catalog No.: PC-35471Not For Human Use, Lab Use Only.
Vafidemstat (ORY-2001, ORY2001) is a potent, selective, brain penetrant dual lysine-specific histone demethylase (LSD1, KDM1A)/MAO-B inhibitor with IC50 of 105 nM (KDM1A) and 58 nM (MAO-B).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Vafidemstat (ORY-2001, ORY2001) is a potent, selective, brain penetrant dual lysine-specific histone demethylase (LSD1, KDM1A)/MAO-B inhibitor with IC50 of 105 nM (KDM1A) and 58 nM (MAO-B).
ORY-2001 corrects memory deficit and behavior alterations including aggression and social interaction deficits in SAMP8 mice and social avoidance in the rat rearing isolation model.
ORY-2001 increases the responsiveness of IEGs, induces genes required for cognitive function and reduces neuroinflammation in the brain of mouse models of CNS disease.
| M.Wt | 336.395 | |
| Formula | C19H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,3,4-Oxadiazole-2-methanamine, 5-amino-N-[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]- |
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1. Maes T, et al. PLoS One. 2020 May 29;15(5):e0233468.
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