Velcalcetide |CAS:1262780-97-1 Probechem Biochemicals

Chemical Structure : Velcalcetide

CAS No.: 1262780-97-1

Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

Catalog No.: PC-63560Not For Human Use, Lab Use Only.

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$378	In stock
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Biological Activity

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.
Velcalcetide reduces parathyroid hormone (PTH) levels and corresponding decreases serum calcium, regardless of the baseline level of PTH in vivo.

Physicochemical Properties

M.Wt	1048.259
Formula	C38H73N21O10S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(((S)-2-acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan

References

1. Walter S, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):229-40.

2. Martin KJ, et al. Kidney Int. 2014 Jan;85(1):191-7.

3. Walter S, et al. BMC Nephrol. 2014 May 19;15:81.

4. Martin KJ, et al. Nephrol Dial Transplant. 2014 Feb;29(2):385-92.

Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

Biological Activity

Physicochemical Properties

References

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