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Chemical Structure : Velcalcetide
CAS No.: 1262780-97-1
Catalog No.: PC-63560Not For Human Use, Lab Use Only.
Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.
Velcalcetide reduces parathyroid hormone (PTH) levels and corresponding decreases serum calcium, regardless of the baseline level of PTH in vivo.
| M.Wt | 1048.259 | |
| Formula | C38H73N21O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
S-(((S)-2-acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan |
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1. Walter S, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):229-40.
2. Martin KJ, et al. Kidney Int. 2014 Jan;85(1):191-7.
3. Walter S, et al. BMC Nephrol. 2014 May 19;15:81.
4. Martin KJ, et al. Nephrol Dial Transplant. 2014 Feb;29(2):385-92.
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