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Verdiperstat

Chemical Structure : Verdiperstat

CAS No.: 890655-80-8

Verdiperstat (AZD-3241, AZD3241)

Catalog No.: PC-63145Not For Human Use, Lab Use Only.

Verdiperstat (AZD3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).

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Biological Activity

Verdiperstat (AZD3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
Verdiperstat (AZD3241) inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM.
Verdiperstat (AZD3241) efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease.
Verdiperstat (AZD3241) also demonstrates significant neuroprotection in MSA mouse model.

Physicochemical Properties

M.Wt 253.32
Formula C11H15N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

References

1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.

2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.

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