Chemical Structure : Vialinin A
CAS No.:
858134-23-3
Vialinin A
(Terrestrin A)
Catalog No.: PC-22183Not For Human Use, Lab Use Only.
Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties, inhibits the peptidase activity of USP5/IsoT with IC50 of 5.9 uM, also inhibits the enzymatic activities of USP4 with IC50 of 1.5 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties, inhibits the peptidase activity of USP5/IsoT with IC50 of 5.9 uM, also inhibits the enzymatic activities of USP4 with IC50 of 1.5 uM.
Vialinin A inhibiting the release of TNF-α (IC50= 0.09 nM) from rat basophilic leukemia cells (RBL-2H3 mast cells).
Vialinin A shows no significant inhibition was observed in terms of the UCH-L3, USP2, and USP8 activities.
Vialinin A dampened Th17 differentiation with high expressed USP4.
Physicochemical Properties
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M.Wt
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562.57
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Formula
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C34H26O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4,4'',5',6'-tetrahydroxy-[1,1':4',1''-terphenyl]-2',3'-diyl bis(2-phenylacetate)
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References
1. Yang J, et al. J Immunol. 2015 May 1;194(9):4094-7.
2. Zhang J, et al. Mol Med Rep. 2019 Aug;20(2):1429-1435.
3. Ning F, et al. Pharmacol Res. 2020 Jul;157:104557.
4. Okada K, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4328-31.
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