Vicadrostat | Aldosterone synthase inhibitor

Chemical Structure : Vicadrostat

Vicadrostat (BI 690517, BI-690517)

Catalog No.: PC-24049Not For Human Use, Lab Use Only.

Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase.

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Biological Activity

Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS, CYP11B2, steroid 18-hydroxylase)) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase.

Physicochemical Properties

M.Wt	317.73
Formula	C15H12ClN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzonitrile, 2-chloro-4-[(6R)-6,7-dihydro-6-(hydroxymethyl)-6-methyl-4-oxopyrano[3,4-d]imidazol-3(4H)-yl]-

References

1. Katherine R Tuttle, et al. Lancet. 2024 Jan 27;403(10424):379-390.

2. Patent WO2016014736.

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Vicadrostat (BI 690517, BI-690517)

Biological Activity

Physicochemical Properties

References

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