Vicriviroc maleate | CCR5 antagonist | Probechem Biochemicals

Chemical Structure : Vicriviroc maleate

CAS No.: 599179-03-0

Vicriviroc maleate (SCH417690, SCH-D, MK-7690)

Catalog No.: PC-45199Not For Human Use, Lab Use Only.

Vicriviroc maleate (SCH417690) is a potent, highly selective, and orally bioavailable CCR5 antagonist with Ki of 2.5 nM.

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5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$368	In stock
50 mg	$558	In stock
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Biological Activity

Vicriviroc maleate (SCH417690) is a potent, highly selective, and orally bioavailable CCR5 antagonist with Ki of 2.5 nM.
Vicriviroc maleate (SCH417690) display no affinity for muscarinic receptors (Ki>10 uM).
Vicriviroc maleate (SCH417690) inhibits HIV-1 entry into U-80 cells with IC50 of 0.8 nM, inhibits HIV-1 clinical isolates in PBMC with IC90 of 1-10 nM.
Vicriviroc maleate (SCH417690) exhibits excellent receptor selectivity and oral bioavailability in rats and monkeys.

Physicochemical Properties

M.Wt	649.701
Formula	C32H42F3N5O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperidine, 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-, (2Z)-2-butenedioate (1:1)

References

1. Tagat JR, et al. J Med Chem. 2004 May 6;47(10):2405-8.

2. Marozsan AJ, et al. Virology. 2005 Jul 20;338(1):182-99.

3. Strizki JM, et al. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.

Vicriviroc maleate (SCH417690, SCH-D, MK-7690)

Biological Activity

Physicochemical Properties

References

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