Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Vildagliptin
CAS No.: 274901-16-5
Catalog No.: PC-22850Not For Human Use, Lab Use Only.
Vildagliptin (NVP-LAF237, LAF237) is a potent, selective and orally bio-available DPP-4 (DPP-IV) inhibitor with IC50 of 3.5 nM in primary DPP-IV assay in human Caco-2 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $98 | In stock | |
| 100 mg | $138 | In stock | |
| 500 mg | $278 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Vildagliptin (NVP-LAF237, LAF237) is a potent, selective and orally bio-available DPP-4 (DPP-IV) inhibitor with IC50 of 3.5 nM in primary DPP-IV assay in human Caco-2 cells.
Vildagliptin (NVP-LAF237, LAF237) is a slow-binding DPP IV inhibitor with an association rate constant of 1.4x10(5)M(-1)s(-1) and a K(i) of 17nM.
Vildagliptin (NVP-LAF237, LAF237) is a micromolar inhibitor for dipeptidyl-peptidase 8 and does not significantly inhibit dipeptidyl-peptidase II (EC 3.4.11.2), prolyl oligopeptidase (EC 3.4.21.26), aminopeptidase P (EC 3.4.11.9) or aminopeptidase M (EC 3.4.11.2).
Vildagliptin (NVP-LAF237, LAF237) improves insulin secretion and glucose homeostasis with a profile wholly consistent with increased action of glucagon-like peptide-1.
| M.Wt | 303.41 | |
| Formula | C17H25N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile |
|
1. Villhauer EB, et al. J Med Chem. 2003 Jun 19;46(13):2774-89.
2. Mari A, et al. J Clin Endocrinol Metab. 2005 Aug;90(8):4888-94.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
