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Vipadenant

Chemical Structure : Vipadenant

CAS No.: 442908-10-3

Vipadenant (BIIB-014;BIIB 014;BIIB014)

Catalog No.: PC-42717Not For Human Use, Lab Use Only.

Vipadenant (BIIB014) is a potent and selective A2A adenosine receptor antagonist with Ki of 1.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vipadenant (BIIB014) is a potent and selective A2A adenosine receptor antagonist with Ki of 1.3 nM.
Vipadenant (BIIB014) displays 50-fold selectivity over A1 and A2B, and no activity against A3, P450 isoforms and hERG.
Vipadenant (BIIB014) shows excellent preclinical pharmacokinetics, and demonstrates strong oral activity in commonly used models of Parkinson's disease.

Physicochemical Properties

M.Wt 321.3366
Formula C16H15N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 3-[(4-amino-3-methylphenyl)methyl]-7-(2-furanyl)-

References

1. Gillespie RJ, et al. J Med Chem. 2009 Jan 8;52(1):33-47.

2. Pinna A. Expert Opin Investig Drugs. 2009 Nov;18(11):1619-31.

3. Brooks DJ, et al. Clin Neuropharmacol. 2010 Mar-Apr;33(2):55-60.

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