Catalog No.: PC-24245Not For Human Use, Lab Use Only.
Vitamin B5 calcium (VB5) is a small molecule inhibitor of Golgi phosphoprotein 3 like (GOLPH3L) with Kd of 1.15 uM in ITC assays, effectively blocks the binding of GOLPH3L and STING, subsequently promoting STING-NLRP3-mediated pyroptosis after radiotherapy (RT).
Vitamin B5 calcium (VB5) is a small molecule inhibitor of Golgi phosphoprotein 3 like (GOLPH3L) with Kd of 1.15 uM in ITC assays, effectively blocks the binding of GOLPH3L and STING, subsequently promoting STING-NLRP3-mediated pyroptosis after radiotherapy (RT). VB5 improved the therapeutic efficacy of RT and immune checkpoint blockade by inducing a robust antitumor immune response in mouse models.
Physicochemical Properties
M.Wt
476.54
Formula
C18H32CaN2O10
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
References
1. Sun S, et al. Sci Transl Med. 2025 Mar 5;17(788):eado0020.
