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Volixibat

Chemical Structure : Volixibat

CAS No.: 1025216-57-2

Volixibat (SHP-626;SAR-548304;LUM-002)

Catalog No.: PC-61418Not For Human Use, Lab Use Only.

Volixibat (SHP-626;SAR-548304;LUM-002) is a highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Volixibat (SHP-626;SAR-548304;LUM-002) is a highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).

    Physicochemical Properties

    M.Wt 805.96
    Formula C38H51N3O12S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-[3-[(3S,4R,5R)-3-Butyl-7-(dimethylamino)-3-ethyl-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenyl]-N'-[3-O-(phenylmethyl)-6-O-sulfo-β-D-glucopyranosyl]urea

    References

    1. Siebers N, et al. Eur J Drug Metab Pharmacokinet. 2017 Jul 12. doi: 10.1007/s13318-017-0429-7.

    2. Tiessen RG, et al. BMC Gastroenterol. 2018 Jan 5;18(1):3.

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