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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-ASBT Transporter (SLC10A2)-Volixibat potassium
Volixibat potassium

Chemical Structure : Volixibat potassium

CAS No.: 1431935-92-0

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Volixibat potassium (SHP-626;SAR-548304;LUM-002)

Catalog No.: PC-61419Not For Human Use, Lab Use Only.

A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).

Steatohepatitis

Phase 2 Clinical

Physicochemical Properties

M.Wt 844.045
Formula C38H50KN3O12S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((2R,3R,4S,5R,6R)-4-(benzyloxy)-6-(3-(3-((3S,4R,5R)-3-butyl-7-(dimethylamino)-3-ethyl-4-hydroxy-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b]thiepin-5-yl)phenyl)ureido)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)methyl hydrogen sulfate, potassium salt

References

1. Siebers N, et al. Eur J Drug Metab Pharmacokinet. 2017 Jul 12. doi: 10.1007/s13318-017-0429-7.

2. Tiessen RG, et al. BMC Gastroenterol. 2018 Jan 5;18(1):3.

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