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Vorolanib

Chemical Structure : Vorolanib

CAS No.: 1013920-15-4

Vorolanib (CM-082, X-82, CM082)

Catalog No.: PC-61437Not For Human Use, Lab Use Only.

Vorolanib (CM-082) is an orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vorolanib (CM-082) is an orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities.
Vorolanib (CM-082) inhibits tumor angiogenesis and tumor cell proliferation, and induces tumor cell death.
Vorolanib (CM-082) has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.

Physicochemical Properties

M.Wt 439.4914
Formula C23H26FN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,Z)-N-(1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

References

1. Jackson TL, et al. JAMA Ophthalmol. 2017 Jul 1;135(7):761-767.

2. Hussain RM, et al. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.

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