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Vutiglabridin

Chemical Structure : Vutiglabridin

CAS No.: 1800188-47-9

Vutiglabridin (HSG4112)

Catalog No.: PC-73455Not For Human Use, Lab Use Only.

Vutiglabridin (HSG4112) is a synthetic structural analog of glabridin and insulin sensitizer, novel anti-obesity agent.

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Biological Activity

Vutiglabridin (HSG4112) is a synthetic structural analog of glabridin and insulin sensitizer, novel anti-obesity agent.
HSG4112 dose-dependently reduces body weight and normalizes obesity-related parameters in HFD-induced obese mice orally administered with 10, 30, or 100 mg/kg dose for 6 weeks.
HSG4112 enhances energy expenditure in HFD-induced obese mice.
HSG4112 regulates metabolic gene expression toward increased energy expenditure in liver and muscles.
HSG4112 ameliorates fatty liver in HFD-induced obese mice orally administered with 100 mg/kg dose for 6 weeks

Physicochemical Properties

M.Wt 354.446
Formula C22H26O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(8,8-dimethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-3-yl)-5-ethoxyphenol

References

1. Choi LS, et al. Int J Obes (Lond). 2021 Jan;45(1):130-142.

2. Bae IY, et al. Pharmaceutics. 2020 Feb 3;12(2):127.

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