WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM).
WAY-200070 induces galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain, causes and learn the socially acquired preferenc in mice.
WAY-200070 deonstrates the anxiolytic-like and antidepressant-like effects in vivo.
Physicochemical Properties
M.Wt
306.11152
Formula
C13H8BrNO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 31 mg/mL
Chemical Name/SMILES
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
References
1. Hughes ZA, et al. Neuropharmacology. 2008 Jun;54(7):1136-42.
2. Clipperton AE, et al. Neuropsychopharmacology. 2008 Sep;33(10):2362-75.
3. Malamas MS, et al. J Med Chem. 2004 Oct 7;47(21):5021-40.
