 
                Chemical Structure : WBC100
CAS No.: 2095780-08-6
Catalog No.: PC-72923Not For Human Use, Lab Use Only.
WBC100 (WBC-100) is a novel potent, oral active that selectively degrades c-Myc protein over other proteins and potently kills c-Myc overexpressing cancer cell.
| Packing | Price | Stock | Quantity | 
|---|---|---|---|
| 1 mg | $228 | In stock | |
| 5 mg | $548 | In stock | |
| 10 mg | $798 | In stock | |
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| 100 mg | Get quote | 
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	WBC100 (WBC-100) is a novel potent, oral active that selectively degrades c-Myc protein over other proteins and potently kills c-Myc overexpressing cancer cell.
	selectively kills c-Myc overexpressing cancer cells Mia-paca2 (PDAC), H9 (T-cell lymphoma), and
	MOLM-13 (acute myeloid leukemia) with IC5 of 61, 17 and 16 nM, respectively.
	WBC100 targets the nuclear localization signal 1 (NLS1)-Basic-nuclear localization signal 2 (NLS2) region of c-Myc and induces c-Myc protein degradation through ubiquitin E3 ligase CHIP mediated 26S proteasome pathway, leading to apoptosis of cancer cells.
	WBC100 potently regresses multiple lethal c-Myc overexpressing tumors such as acute myeloid leukemia, pancreatic, and gastric cancers with good tolerability in multiple xenograft mouse models.
| M.Wt | 459.539 | |
| Formula | C25H33NO7 | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | (6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl L-valinate | |
1. Xu Y, et al. Adv Sci (Weinh). 2022 Jan 20:e2104344.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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