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WEHI-600

Chemical Structure : WEHI-600

CAS No.: 2363124-79-0

WEHI-600 (Cbz-Cav(NH2)-Phg-Sta-NH(CH2)2Ph.TFA)

Catalog No.: PC-49833Not For Human Use, Lab Use Only.

WEHI-600 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 3 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=7 nM).

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    Biological Activity

    WEHI-600 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 3 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=7 nM).

    Physicochemical Properties

    M.Wt 817.86
    Formula C37H49N7O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    benzyl ((6S,9S,12S,13S)-1-amino-13-hydroxy-1-imino-12-isobutyl-7,10,15-trioxo-9,18-diphenyl-3-oxa-2,8,11,16-tetraazaoctadecan-6-yl)carbamate 2,2,2-trifluoroacetate

    References

    1. William Nguyen, et al. Eur J Med Chem. 2018 Jun 25;154:182-198.

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