WEHI-601 | Pf PMX inhibitor | Probechem Biochemicals

Chemical Structure : WEHI-601

WEHI-601 (Cbz-Cav(NH2)-CyHexGly-Sta-NH(CH2)2PH.TFA)

Catalog No.: PC-49832Not For Human Use, Lab Use Only.

WEHI-601 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 5 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=9 nM).

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Biological Activity

WEHI-601 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 5 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=9 nM).

Physicochemical Properties

M.Wt	823.91
Formula	C39H56F3N7O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl ((6S,9S,12S,13S)-1-amino-9-cyclohexyl-13-hydroxy-1-imino-12-isobutyl-7,10,15-trioxo-18-phenyl-3-oxa-2,8,11,16-tetraazaoctadecan-6-yl)carbamate 2,2,2-trifluoroacetate

References

1. William Nguyen, et al. Eur J Med Chem. 2018 Jun 25;154:182-198.

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WEHI-601 (Cbz-Cav(NH2)-CyHexGly-Sta-NH(CH2)2PH.TFA)

Biological Activity

Physicochemical Properties

References

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