Chemical Structure : WEHI-991
CAS No.:
WEHI-991
(W-991)
Catalog No.: PC-22543Not For Human Use, Lab Use Only.
WEHI-991 (W-991) is a potent small molecule inhibitor of PfSTART1 with antiparasitic activity EC50 of 7 nM for Pf 3D7, binds to PfSTART1(WT) with KD of 10 nM, inhibits ring-stage development of Plasmodium falciparum.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WEHI-991 (W-991) is a potent small molecule inhibitor of PfSTART1 with antiparasitic activity EC50 of 7 nM for Pf 3D7, binds to PfSTART1(WT) with KD of 10 nM, inhibits ring-stage development of Plasmodium falciparum.
The PfSTART1 mutations confer resistance to, bu still reteins with sub-micromolar potency against the mutant parasites with an EC50 below 700 nM.
W-991 (WEHI-991) blocks Plasmodium falciparum ring development but the effect is reversible.
W-991 (WEHI-991) blocks differentiation into ring-stage parasites by preventing parasitophorous vacuole membrane (PVM) expansion.
W-991 (WEHI-991) does not prevent sporozoite invasion but blocks parasite transmission to mosquitoes.
Physicochemical Properties
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M.Wt
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490.37
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Formula
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C20H22Cl2FN3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((4-chloro-3-(morpholinosulfonyl)phenyl)amino)-N-(3-chloro-4-fluorophenyl)-2-methylpropanamide
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References
1. Madeline G Dans, et al. Nat Commun. 2024 Jun 18;15(1):5219.
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