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Chemical Structure : WEHI-991
Catalog No.: PC-22543Not For Human Use, Lab Use Only.
WEHI-991 (W-991) is a potent small molecule inhibitor of PfSTART1 with antiparasitic activity EC50 of 7 nM for Pf 3D7, binds to PfSTART1(WT) with KD of 10 nM, inhibits ring-stage development of Plasmodium falciparum.
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WEHI-991 (W-991) is a potent small molecule inhibitor of PfSTART1 with antiparasitic activity EC50 of 7 nM for Pf 3D7, binds to PfSTART1(WT) with KD of 10 nM, inhibits ring-stage development of Plasmodium falciparum.
The PfSTART1 mutations confer resistance to, bu still reteins with sub-micromolar potency against the mutant parasites with an EC50 below 700 nM.
W-991 (WEHI-991) blocks Plasmodium falciparum ring development but the effect is reversible.
W-991 (WEHI-991) blocks differentiation into ring-stage parasites by preventing parasitophorous vacuole membrane (PVM) expansion.
W-991 (WEHI-991) does not prevent sporozoite invasion but blocks parasite transmission to mosquitoes.
| M.Wt | 490.37 | |
| Formula | C20H22Cl2FN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Madeline G Dans, et al. Nat Commun. 2024 Jun 18;15(1):5219.
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