WGU55 | TMPRSS6 inhibitor | Probechem Biochemicals

Chemical Structure : WGU55

WGU55 ((H)Phe- Bip -Asp- Arg -Kbt)

Catalog No.: PC-26184Not For Human Use, Lab Use Only.

WGU55 is a potent, selective peptidomimetic TMPRSS6 inhibitor with Ki of 12.15 nM and IC50 of 138 nM in TMPRSS6-transfected HEK293 cells, shows >200-fold selectivity over matriptase, Factor Xa and Thrombin.

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Biological Activity

Physicochemical Properties

M.Wt	761.90
Formula	C41H43N7O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((S)-3-([1,1'-biphenyl]-4-yl)-2-(3-phenylpropanamido)propanamido)-4-(((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)amino)-4-oxobutanoic acid

References

1. Walid Guerrab, et al. J Med Chem. 2025 Dec 25;68(24):26012-26029.

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WGU55 ((H)Phe- Bip -Asp- Arg -Kbt)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

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