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WHZ-13

Chemical Structure : WHZ-13

CAS No.: 2361563-00-8

WHZ-13

Catalog No.: PC-27570Not For Human Use, Lab Use Only.

WHZ-13 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 4.1 nM for Pf20S β5, has 91-fold and 24-fold selectivity over β5c and β5i, shows antimalarial EC50 of 3.1 nM against Pf 3D7.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WHZ-13 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 4.1 nM for Pf20S β5, has 91-fold and 24-fold selectivity over β5c and β5i, shows antimalarial EC50 of 3.1 nM against Pf 3D7.

Physicochemical Properties

M.Wt 512.63
Formula C26H32N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N4-(tert-butyl)-N1-(2-(3-ethynylbenzamido)ethyl)-2-((4-methylphenyl)sulfonamido)succinamide

References

1. Wenhu Zhan, et al. J Med Chem. 2019 Jul 11;62(13):6137-6145.

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