WJYK50 | ASM inhibitor | Probechem Biochemicals

Chemical Structure : WJYK50

WJYK50 (ASM inhibitor 1c)

Catalog No.: PC-24104Not For Human Use, Lab Use Only.

WJYK50 (ASM inhibitor 1c) is a potent, selective inhibitor of acid sphingomyelinase (ASM) with IC50 of 0.48 uM, inhibits the generation of ceramide in a dose-dependent manner.

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Biological Activity

WJYK50 (ASM inhibitor 1c) is a potent, selective inhibitor of acid sphingomyelinase (ASM) with IC50 of 0.48 uM, inhibits the generation of ceramide in a dose-dependent manner.
WJYK50 showed favorable anti-apoptosis and anti-inflammatory activity.
WJYK50 restored the ceramide level in the apoptosis assay.

Physicochemical Properties

M.Wt	321.46
Formula	C19H31NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-methoxy-3-undecylbenzamide

References

1. Kan Yang, et al. Eur J Med Chem. 2018 May 10:151:389-400.

2. Yang K, et al. J Med Chem. 2023 Feb 23;66(4):2681-2698.

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WJYK50 (ASM inhibitor 1c)

Biological Activity

Physicochemical Properties

References

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