WS-12 (Acoltremon, AR-15512, AVX-012) is a potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent.
WS-12 displays higher potency and efficacy compared to menthol (EC50=193 uM), does activates thermo-sensitive TRP ion channel including TRPV1, TRPV2, TRPV3, TRPV4 and TRPA1 at 1 mM.
WS-12 accelerates skin permeability barrier recovery, also reduces epidermal proliferation associated with barrier disruption.
