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WS-383

Chemical Structure : WS-383

CAS No.: 2247543-65-1

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WS-383 (WS383;WS 383)

Catalog No.: PC-36111Not For Human Use, Lab Use Only.

WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
    WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2.
    WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM.

    Physicochemical Properties

    M.Wt 461.991
    Formula C18H20ClN9S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(5-((2-((4-Chlorobenzyl)thio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio )-1H-tetrazol-1-yl)-N,N-dimethylethan-1-amine

    References

    1. Wang S, et al. J Med Chem. 2019 Feb 25. doi: 10.1021/acs.jmedchem.9b00113.

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