WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2.
WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM.
