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Chemical Structure : WS6
CAS No.: 1421227-53-3
Catalog No.: PC-43043Not For Human Use, Lab Use Only.
WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.
WS6 promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.
WS6 acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription;.
WS6 also stimulates α cell proliferation in human pancreatic islets.
WS6 depletes EVI1 and MYC signaling and blocks 3q26 AML in vivo
| M.Wt | 568.59 | |
| Formula | C29H31F3N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzeneacetamide, 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- |
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1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
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