Catalog No.: PC-43043Not For Human Use, Lab Use Only.
WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.
WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.
WS6 promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.
WS6 acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription;.
WS6 also stimulates α cell proliferation in human pancreatic islets.
WS6 depletes EVI1 and MYC signaling and blocks 3q26 AML in vivo
