WY-14643 |CAS:50892-23-4 Probechem Biochemicals

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Chemical Structure : WY-14643

CAS No.: 50892-23-4

WY-14643 (Pirinixic acid, WY14643)

Catalog No.: PC-45121Not For Human Use, Lab Use Only.

A potent, selective PPARα agonist with EC50 of 0.63 uM.

Packing	Price	Stock
50 mg	$58	In stock
100 mg	$88	In stock
250 mg	$148	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

WY-14643 (Pirinixic acid) is a potent, selective PPARα agonist with EC50 of 0.63 uM.
WY-14643 displays little or no activity for PPARγ and PPARδ (EC50=32 and >100 uM, respectively).
WY-14643 modulates cellular redox status, represses NF-kappaB signaling, and reduces inflammatory cytokine production in mice.

Physicochemical Properties

M.Wt	323.7979
Formula	C14H14ClN3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: 15 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-

References

1. Willson TM, et al. J Med Chem. 2000 Feb 24;43(4):527-50.

2. Forman BM, et al. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.

3. Poynter ME, et al. J Biol Chem. 1998 Dec 4;273(49):32833-41.

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WY-14643 (Pirinixic acid, WY14643)

Biological Activity

Physicochemical Properties

References

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