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Chemical Structure : WY-14643
CAS No.: 50892-23-4
Catalog No.: PC-45121Not For Human Use, Lab Use Only.
A potent, selective PPARα agonist with EC50 of 0.63 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $88 | In stock | |
| 250 mg | $148 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
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WY-14643 (Pirinixic acid) is a potent, selective PPARα agonist with EC50 of 0.63 uM.
WY-14643 displays little or no activity for PPARγ and PPARδ (EC50=32 and >100 uM, respectively).
WY-14643 modulates cellular redox status, represses NF-kappaB signaling, and reduces inflammatory cytokine production in mice.
| M.Wt | 323.7979 | |
| Formula | C14H14ClN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- |
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1. Willson TM, et al. J Med Chem. 2000 Feb 24;43(4):527-50.
2. Forman BM, et al. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.
3. Poynter ME, et al. J Biol Chem. 1998 Dec 4;273(49):32833-41.
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