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WYC-209

Chemical Structure : WYC-209

CAS No.: 2131803-90-0

WYC-209 (WYC209)

Catalog No.: PC-63510Not For Human Use, Lab Use Only.

WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).

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Biological Activity

WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).
WYC-209 also inhibits proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.
WYC-209 abrogates lung metastases of melanoma TRCs in immune-competent wild-type C57BL/6 mice at 0.22 mg/kg without showing apparent toxicity.
WYC-209 induces TRCs apoptosis primarily via the caspase 3 pathway, RAR siRNAs or antagonists can block or reduce the inhibitory effect of WYC-209.

Physicochemical Properties

M.Wt 368.451
Formula C20H20N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate

References

1. Chen J, et al. Nat Commun. 2018 Apr 11;9(1):1406.

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