Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : WYC-209
CAS No.: 2131803-90-0
Catalog No.: PC-63510Not For Human Use, Lab Use Only.
WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).
WYC-209 also inhibits proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.
WYC-209 abrogates lung metastases of melanoma TRCs in immune-competent wild-type C57BL/6 mice at 0.22 mg/kg without showing apparent toxicity.
WYC-209 induces TRCs apoptosis primarily via the caspase 3 pathway, RAR siRNAs or antagonists can block or reduce the inhibitory effect of WYC-209.
| M.Wt | 368.451 | |
| Formula | C20H20N2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate |
|
1. Chen J, et al. Nat Commun. 2018 Apr 11;9(1):1406.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
