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Chemical Structure : WYE-151650
Catalog No.: PC-62971Not For Human Use, Lab Use Only.
WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
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WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively; inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes, exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation; inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models.
| M.Wt | 435.487 | |
| Formula | C26H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lin TH, et al. Arthritis Rheum. 2010 Aug;62(8):2283-93.
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