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Warfarin

Chemical Structure : Warfarin

CAS No.: 81-81-2

Warfarin (WARF-42, Athrombine-K)

Catalog No.: PC-23520Not For Human Use, Lab Use Only.

Warfarin (WARF-42, Athrombine-K) is a potent anticoagulant agent and a vitamin K1 recycling antagonist to deplete active vitamin K1, is a small molecular inhibitor of vitamin K epoxide reductase complex subunit 1 like 1 (VKORC1L1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Warfarin (WARF-42, Athrombine-K) is a potent anticoagulant agent and a vitamin K1 recycling antagonist to deplete active vitamin K1, is a small molecular inhibitor of vitamin K epoxide reductase complex subunit 1 like 1 (VKORC1L1).
Warfarin promotes ferroptosis, represses tumor growth by promoting ferroptosis in both immunodeficient and immunocompetent mouse models.
Warfarin is a potential repurposing drug in cancer therapy, particularly for tumors with high levels of VKORC1L1 expression.

Physicochemical Properties

M.Wt 308.33
Formula C19H16O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-

References

1. Yang X, et al. Cell Metab. 2023 Aug 8;35(8):1474-1490.e8.

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