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XDM-CBP

Chemical Structure : XDM-CBP

CAS No.: 2138461-99-9

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XDM-CBP (XDM CBP)

Catalog No.: PC-61151Not For Human Use, Lab Use Only.

XDM-CBP is a highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    XDM-CBP is a highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family.
    XDM-CBP exhibits antiproliferative effect on numerous cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia (HL-60 and MCF-7 cells GI50=1.3 and 4.2 uM, respectively).

    Physicochemical Properties

    M.Wt 366.417
    Formula C21H22N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-acetyl-N-((2,8-dihydroxynaphthalen-1-yl)methyl)-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

    References

    1. Hügle M, et al. Angew Chem Int Ed Engl. 2017 Aug 2. doi: 10.1002/anie.201705516.

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