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Chemical Structure : XEN445
CAS No.: 1515856-92-4
Catalog No.: PC-42932Not For Human Use, Lab Use Only.
XEN445 is a potent, selective endothelial lipase (EL) inhibitor with IC50 of 237 nM, displays no significant activity against lipoprotein lipase (LPL) and hepatic lipase (HL) (IC50=20 and 9.5 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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XEN445 is a potent, selective endothelial lipase (EL) inhibitor with IC50 of 237 nM, displays no significant activity against lipoprotein lipase (LPL) and hepatic lipase (HL) (IC50=20 and 9.5 uM).
XEN445 demonstrates in vivo efficacy in raising plasma HDLc concentrations in mice, shows good ADME and PK properties.
| M.Wt | 366.3344 | |
| Formula | C18H17F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)- |
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1. Sun S, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34.
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