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Chemical Structure : XIB-4035
Catalog No.: PC-70338Not For Human Use, Lab Use Only.
(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).
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(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).
(E)-Aminoquinol (XIB-4035) concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM.
(E)-Aminoquinol (XIB-4035) induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.
| M.Wt | 456.45 | |
| Formula | C26H31Cl2N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hedstrom KL, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30.
2. Tokugawa K, et al. Neurochem Int. 2003 Jan;42(1):81-6.
3. Höke A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1.
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