(E)-Aminoquinol (XIB-4035) | GFRα-1 agonist

Chemical Structure : XIB-4035

XIB-4035 (XIB4035, (E)-Aminoquinol)

Catalog No.: PC-70338Not For Human Use, Lab Use Only.

(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).

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Biological Activity

(E)-Aminoquinol (XIB-4035) is a nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1).
(E)-Aminoquinol (XIB-4035) concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM.
(E)-Aminoquinol (XIB-4035) induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.

Physicochemical Properties

M.Wt	456.45
Formula	C26H31Cl2N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-[7-Chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-1,4-pentanediamine

References

1. Hedstrom KL, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30.

2. Tokugawa K, et al. Neurochem Int. 2003 Jan;42(1):81-6.

3. Höke A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1.

XIB-4035 (XIB4035, (E)-Aminoquinol)

Biological Activity

Physicochemical Properties

References

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