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Chemical Structure : XL-126
Catalog No.: PC-21732Not For Human Use, Lab Use Only.
XL-126 (XL126) is a potent BD1-selective BET inhibitor with SPR binding KD value of 8.9 nM, has 185-fold BD1/BD2 selectivity.
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XL-126 (XL126) is a potent BD1-selective BET inhibitor with SPR binding KD value of 8.9 nM, has 185-fold BD1/BD2 selectivity.
XL-126 shows an IC50 of 11.9 nM for BRD4 BD1 and a 261-fold selectivity over BRD4 BD2 in TR-FRET assays.
XL-126 demonstrates concentration-dependent inhibition of IL-6 production induces by LPS in murine macrophage J-774 cells (IC50=178 nM).
XL-126 (30 mg/kg, i.p.) exhibits potent anti-inflammatory efficacy, with no significant decrease in platelet count.
| M.Wt | 611.77 | |
| Formula | C33H37N7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yangfeng Li, et al. J Med Chem. 2024 Jan 31. doi: 10.1021/acs.jmedchem.3c01837.
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