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Chemical Structure : XL188
CAS No.: 2305045-76-3
Catalog No.: PC-60494Not For Human Use, Lab Use Only.
XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
XL188 exhibits little to no inhibition against a panel of 41 DUBs.
XL188 promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM.
XL188 is a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.
| M.Wt | 574.726 | |
| Formula | C32H42N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-3-(4-methylpiperazin-1-yl)propanamide |
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1. Lamberto I, et al. Cell Chem Biol. 2017 Sep 28. pii: S2451-9456(17)30329-X.
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