Catalog No.: PC-60494Not For Human Use, Lab Use Only.
XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
XL188 exhibits little to no inhibition against a panel of 41 DUBs.
XL188 promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM.
XL188 is a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.
