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XL784

Chemical Structure : XL784

CAS No.: 1224964-36-6

XL784 (XL-784)

Catalog No.: PC-26512Not For Human Use, Lab Use Only.

XL784 is a potent limited-spectrum MMP inhibitor with IC50 of 0.81, 120, 10.8, 18, 0.56 nM for MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, also inhibits snake venom metalloproteinase (SVMP) toxin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

XL784 is a potent limited-spectrum MMP inhibitor with IC50 of 0.81, 120, 10.8, 18, 0.56 nM for MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, also inhibits snake venom metalloproteinase (SVMP) toxin.

Physicochemical Properties

M.Wt 548.92
Formula C21H22ClF2N3O8S.1/2Mg
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[[4-(4-chlorophenoxy)-3,5-difluorophenyl]sulfonyl]-3-[(hydroxyamino)carbonyl]-, 2-methoxyethyl ester, magnesium salt (2:1)

References

1. Rachel H Clare, et al. Front Pharmacol. 2024 Jan 11:14:1328950.

2. Ennis T, et al. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26.

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