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Chemical Structure : XMD8-85
Catalog No.: PC-72142Not For Human Use, Lab Use Only.
XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.
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XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.
XMD8-85 is selective for ERK5 over tyrosine non-receptor kinase 2 (TNK2, IC50=959 nM), but does inhibit the leucine-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S (IC50 = 26 nM).
XMD8-85 inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50= 0.19 μM).
XMD8-85 also inhibits Brd4/BET family bromodomains, transcriptional regulators required for Nanog expression.
| M.Wt | 459.5 | |
| Formula | C25H29N7O2 | |
| Appearance | Solid | |
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1. Deng, X, et al. Eur. J. Med. Chem. 70, 758-767 (2013).
3. Di Micco R., et al. Cell Rep. 2014;9:234–247.
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