Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : XMD8-85
CAS No.: 1234479-76-5
Catalog No.: PC-72142Not For Human Use, Lab Use Only.
XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay.
XMD8-85 is selective for ERK5 over tyrosine non-receptor kinase 2 (TNK2, IC50=959 nM), but does inhibit the leucine-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S (IC50 = 26 nM).
XMD8-85 inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50= 0.19 μM).
XMD8-85 also inhibits Brd4/BET family bromodomains, transcriptional regulators required for Nanog expression.
| M.Wt | 459.5 | |
| Formula | C25H29N7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-((2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one |
|
1. Deng, X, et al. Eur. J. Med. Chem. 70, 758-767 (2013).
3. Di Micco R., et al. Cell Rep. 2014;9:234–247.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
