Catalog No.: PC-61297Not For Human Use, Lab Use Only.
XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
XRK3F2 inhibits TNFα-induced osteoclast formation, and has IC50 of 4.35 uM 5TGM1 cells and 4.6 uM for the human MM1.S cell line.
XRK3F2 induces new cortical bone formation in MMBD in vivo, and alters MM cell-BMSC cell interactions by reducing MM cell-derived TNFα in the myeloma microenvironment.
