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Chemical Structure : XS-060
Catalog No.: PC-20839Not For Human Use, Lab Use Only.
XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
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XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
XS-060 binds to RXRα with Kd=1.3 μM and effectively induces mitotic arrest and chromosome aberrations in an RXRα-dependent and cancer-specific manner.
XS-060 displays a promising anticancer activity in vitro and in vivo.
| M.Wt | 334.38 | |
| Formula | C20H18N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Q, et al. Bioorg Chem. 2022 Nov;128:106069.
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