XS-060 | RXRα inhibitor | Probechem Biochemicals

Chemical Structure : XS-060

XS-060 (XS060)

Catalog No.: PC-20839Not For Human Use, Lab Use Only.

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Biological Activity

XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
XS-060 binds to RXRα with Kd=1.3 μM and effectively induces mitotic arrest and chromosome aberrations in an RXRα-dependent and cancer-specific manner.
XS-060 displays a promising anticancer activity in vitro and in vivo.

Physicochemical Properties

M.Wt	334.38
Formula	C20H18N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CC3=CC=C(OC)C=C3

References

1. Wang Q, et al. Bioorg Chem. 2022 Nov;128:106069.

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XS-060 (XS060)

Biological Activity

Physicochemical Properties

References

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