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Chemical Structure : XST-20
Catalog No.: PC-38900Not For Human Use, Lab Use Only.
XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.
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XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.
XST-20 (40 μM, 48h) exhibited a significant inhibitor effect on both A2780 and SKOV3 cells, downregulated FOXM1 downstream targets CCNB1 and CDC25B expression.
XST-20 (25 and 50 μM) significantly reduced the protein level of CCNB1 and PLK1 while FOXM1 protein level was not changed in ovarian cancer cell lines.
XST-20 significantly reduced the colony-forming efficiency and induced cell cycle arrest and apoptosis.
| M.Wt | 355.478 | |
| Formula | C22H29NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zaixin Zhang, et al. Cell Death Discov. 2022 Jun 9;8(1):280.
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