Catalog No.: PC-38900Not For Human Use, Lab Use Only.
XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.
XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.
XST-20 (40 μM, 48h) exhibited a significant inhibitor effect on both A2780 and SKOV3 cells, downregulated FOXM1 downstream targets CCNB1 and CDC25B expression.
XST-20 (25 and 50 μM) significantly reduced the protein level of CCNB1 and PLK1 while FOXM1 protein level was not changed in ovarian cancer cell lines.
XST-20 significantly reduced the colony-forming efficiency and induced cell cycle arrest and apoptosis.
