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Chemical Structure : XY153
Catalog No.: PC-73224Not For Human Use, Lab Use Only.
XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.
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XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.
XY153 displays 6-fold BRD4 BD2 domain selectivity over other BET BD2 domains.
XY153 displayed potent antiproliferative activity against multiple tumor cell lines, especially MV4-11 (IC50=0.55 nM), also demonstrated good metabolic stability in vitro.
| M.Wt | 555.650 | |
| Formula | C33H34FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Junhua Li, et al. J Med Chem. 2022 Mar 25. doi: 10.1021/acs.jmedchem.2c00100.
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