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XY153

Chemical Structure : XY153

CAS No.: 2933176-32-8

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XY153 (XY 153)

Catalog No.: PC-73224Not For Human Use, Lab Use Only.

XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1.
    XY153 displays 6-fold BRD4 BD2 domain selectivity over other BET BD2 domains.
    XY153 displayed potent antiproliferative activity against multiple tumor cell lines, especially MV4-11 (IC50=0.55 nM), also demonstrated good metabolic stability in vitro.

    Physicochemical Properties

    M.Wt 555.650
    Formula C33H34FN3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-cyclopentyl-1H-imidazol-5-yl)-7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one

    References

    1. Junhua Li, et al. J Med Chem. 2022 Mar 25. doi: 10.1021/acs.jmedchem.2c00100.

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