Chemical Structure : Xanomeline
CAS No.:
131986-45-3
Xanomeline
(LY246708, NNC 110232)
Catalog No.: PC-25835Not For Human Use, Lab Use Only.
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens).
Xanomeline displays low affinity for M2 receptors in guinea pig atria (EC50=3 uM).
Xanomeline increases striatal levels of dopamine metabolites, presumably by acting at M1 heteroreceptors on dopamine neurons to increase dopamine release in vivo.
Xanomeline inhibits ex vivo binding of muscarinic radioligands to homogenates of brain and the inhibition of ex vivo binding occurred in the same dose range as increases in DOPAC levels.
Xanomeline is selective agonist for M1 over M2 and M3 receptors in vivo in rats.
Physicochemical Properties
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M.Wt
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281.42
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Formula
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C14H23N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-
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References
1. Shannon HE, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81.
2. Sauerberg P, et al. J Med Chem. 1992 Jun 12;35(12):2274-83.
3. Bymaster FP, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):282-9.
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