Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Y180
Catalog No.: PC-38696Not For Human Use, Lab Use Only.
Y180 is a highly potent, selective, covalent, and orally active SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 8.1 nM in enzymatic assays, binding Ki value of 1 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Y180 is a highly potent, selective, covalent, and orally active SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 8.1 nM in enzymatic assays, binding Ki value of 1 nM.
Y180 showed almost no activity against several common mammalian proteases with similar structure, including caspase 2, chymotrypsin, thrombin, cathepsin B, cathepsin D and cathepsin L (IC50>100 uM).
Y180 protected against wild-type SARS-CoV-2, B.1.1.7 (Alpha), B.1.617.1 (Kappa) and P.3 (Theta), with EC50 of 11.4, 20.3, 34.4 and 23.7 nM, respectively.
Y180 displayed a remarkable antiviral potency and substantially ameliorated the virus-induced tissue damage in both nasal turbinate and lung of B.1.1.7-infected K18-human ACE2 (K18-hACE2) transgenic mice.
Y180 improved the survival of mice in the lethal B.1.617.1 infection model, also highly effective against the B.1.1.529 (Omicron) variant both in vitro and in vivo.
| M.Wt | 510.544 | |
| Formula | C30H23DFN3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Quan BX, et al. Nat Microbiol. 2022 May;7(5):716-725.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
