Chemical Structure : YB-3-17
CAS No.:
2940242-88-4
YB-3-17
Catalog No.: PC-23566Not For Human Use, Lab Use Only.
YB-3-17 is a potent dual-target, dual-mechanism molecule, robustly inhibits mTOR (IC50=0.22 nM) and selectively degrades GSPT1 (DC50=5 nM, U87 cells).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YB-3-17 is a potent dual-target, dual-mechanism molecule, robustly inhibits mTOR (IC50=0.22 nM) and selectively degrades GSPT1 (DC50=5 nM, U87 cells).
YB-3-17 significantly inhibited the phosphorylation of S6K and 4EBP1 proteins in U87 cells in concentration- and time-dependent manners, also downregulates phosphorylation of the AKT protein.
YB-3-17 efficiently inhibited the proliferation of various glioblastoma cells, achieving IC50 values as low as 3.3 nM.
YB-3-17 significantly degrades only GSPT1 without affecting other intracellular proteins, does not inhibit off-targets such as FGR, CSF1R (FMS), LCK, and LYNa.
YB-3-17 not only significantly outperforms the inhibitor MLN0128 in tumor suppression activity, demonstrating a more robust anticancer effect, but also exhibits superior safety.
Physicochemical Properties
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M.Wt
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745.80
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Formula
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C38H39N11O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(((4-(4-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)cyclohexyl)methyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
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References
1. Liu Y, et al. J Am Chem Soc. 2024 Dec 2. doi: 10.1021/jacs.4c11930.
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