Catalog No.: PC-35071Not For Human Use, Lab Use Only.
YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin.
YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin.
YC-001 demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity.
YC-001 binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant.
YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration.
