YCH3124 | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : YCH3124

YCH3124 (Compound Z33)

Catalog No.: PC-22877Not For Human Use, Lab Use Only.

YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25.

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Biological Activity

YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25.
YCH3124 exhibits 4- to 11-fold greater potency than FT671 against in various p53 wild-type cell lines, including CHP-212, LNCaP, MM1.S, and MV-4-11 cells, with IC50 of 3.6-52.3 nM.
YCH3124 induces p53-dependent cell growth inhibition, with dose-dependent reduction in both DNMT1 and Rad18 proteins.
YCH3124 treatment induces cell cycle arrest and apoptosis.

Physicochemical Properties

M.Wt	530.63
Formula	C30H34N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-7-(3,4-dimethoxyphenyl)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

References

1. Zhuang Z, et al. Eur J Med Chem. 2024 Aug 5;277:116752.

YCH3124 (Compound Z33)

Biological Activity

Physicochemical Properties

References

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