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Chemical Structure : YCH3124
Catalog No.: PC-22877Not For Human Use, Lab Use Only.
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25.
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YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25.
YCH3124 exhibits 4- to 11-fold greater potency than FT671 against in various p53 wild-type cell lines, including CHP-212, LNCaP, MM1.S, and MV-4-11 cells, with IC50 of 3.6-52.3 nM.
YCH3124 induces p53-dependent cell growth inhibition, with dose-dependent reduction in both DNMT1 and Rad18 proteins.
YCH3124 treatment induces cell cycle arrest and apoptosis.
| M.Wt | 530.63 | |
| Formula | C30H34N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhuang Z, et al. Eur J Med Chem. 2024 Aug 5;277:116752.
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