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Chemical Structure : YE6144
CAS No.:
Catalog No.: PC-72048Not For Human Use, Lab Use Only.
YE6144 (YE 6144) is a specific small molecule inhibitor of transcription factor IFN regulatory factor 5 (IRF5), selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation.
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YE6144 (YE 6144) is a specific small molecule inhibitor of transcription factor IFN regulatory factor 5 (IRF5), selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation.
YE6144 inhibited the phosphorylation of IRF5 in both human PBMCs and mouse splenocytes, decreased the production of type I IFNs (IFN-β and IFN-α) in human PBMCs stimulated with R-848 with IC50 of 0.09 uM.
YE6144 administration maintains the remission and alleviated the disease course in the NZB/W F1 mouse model of autoimmune disease systemic lupus erythematosus (SLE).
| M.Wt | 447.943 | |
| Formula | C21H27ClFN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,E)-N1-(6-fluoro-3-(2-(6-morpholinopyridazin-3-yl)vinyl)-1H-indazol-5-yl)butane-1,2-diamine hydrochloride |
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1. Tatsuma Ban, et al. Nat Commun. 2021 Jul 19;12(1):4379.
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