Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : YHO-13177
CAS No.: 912287-56-0
Catalog No.: PC-43181Not For Human Use, Lab Use Only.
YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $108 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $858 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; reverses BCRP-mediated acquired resistance to SN-38 in A549 cells without cytotoxicity, also shows no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
| M.Wt | 370.4653 | |
| Formula | C20H22N2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzeneacetonitrile, α-[[5-(4-hydroxy-1-piperidinyl)-2-thienyl]methylene]-3,4-dimethoxy-, (αZ)- |
|
1. Yamazaki R, et al. Mol Cancer Ther. 2011 Jul;10(7):1252-63.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
