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Chemical Structure : YK-2168
Catalog No.: PC-23019Not For Human Use, Lab Use Only.
YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.
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YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.
YK-2168 exhibits cell viability potency (IC50=53.4 nM) against MV4-11 cells, inhibits the CDK9 signaling and induced apoptosis.
YK-2168 demonstrated dose dependent anti-tumor effects, resulted in many mouse partial responses (PR) in a mouse gastric cancer SNU16 CDX model.
| M.Wt | 315.81 | |
| Formula | C16H18ClN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu Y, et al. Bioorg Med Chem Lett. 2024 Aug 31:129941.
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