YK-2168 hydrochloride | CDK9 inhibitor

Chemical Structure : YK-2168 hydrochloride

YK-2168 hydrochloride (YK2168 hydrochloride)

Catalog No.: PC-23020Not For Human Use, Lab Use Only.

YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.

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Biological Activity

YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.
YK-2168 exhibits cell viability potency (IC50=53.4 nM) against MV4-11 cells, inhibits the CDK9 signaling and induced apoptosis.
YK-2168 demonstrated dose dependent anti-tumor effects, resulted in many mouse partial responses (PR) in a mouse gastric cancer SNU16 CDX model.

Physicochemical Properties

M.Wt	352.26
Formula	C16H19Cl2N5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrolo[2,3-b]pyridine, 5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-2-(4-piperidinyl)-, hydrochloride (1:1)

References

1. Liu Y, et al. Bioorg Med Chem Lett. 2024 Aug 31:129941.

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YK-2168 hydrochloride (YK2168 hydrochloride)

Biological Activity

Physicochemical Properties

References

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