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Chemical Structure : YK-4-279
CAS No.: 1037184-44-3
Catalog No.: PC-22540Not For Human Use, Lab Use Only.
YK-4-279 is a specific small molecule inhibitor of EWS-FLI1 interaction with RNA helicase A with SPR KD of 9.48 uM for EWS-FLI1, reduces EWS-FLI1 functional activity, also reduces EWS-FLI1 modulated transcription.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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YK-4-279 is a specific small molecule inhibitor of EWS-FLI1 interaction with RNA helicase A with SPR KD of 9.48 uM for EWS-FLI1, reduces EWS-FLI1 functional activity, also reduces EWS-FLI1 modulated transcription.
YK-4-279 specifically inhibits Ewing's Sarcoma Family Tumors (ESFT) cell growth (IC50 values between 0.5 to 2 μM) and induces apoptosis, but not cell death in the non-transformed cells.
YK-4-279 (60-75 mg/kg) inhibits ESFT xenograft growth in CHP-100 xenograft tumors.
| M.Wt | 366.19 | |
| Formula | C17H13Cl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,7-Dichloro-3-hydroxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)indolin-2-one |
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1. Erkizan HV, et al. Nat Med. 2009 Jul;15(7):750-6.
2. Erkizan HV, et al. Clin Cancer Res. 2010 Aug 15;16(16):4077-83.
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